Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors

Variants in ETV6, which encodes a transcription repressor of the E26 transformation-specific family, have recently been reported to be responsible for inherited thrombocytopenia and hematologic malignancy.We sequenced the DNA from cases with unexplained dominant thrombocytopenia and identified six likely pathogenic variants in ETV6, of which five a

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Cooperative interactions in the West Nile virus mutant swarm

Abstract Background RNA viruses including arthropod-borne viruses (arboviruses) exist as highly genetically diverse mutant swarms within individual hosts.A more complete understanding of the phenotypic correlates of these diverse swarms is needed in order to equate Insulated Dinnerware RNA swarm breadth and composition to specific adaptive and evol

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Simulation of passenger movement dynamics in a vehicle

Support The article deals with the problem of modeling the movement of passengers in Artbook the interior of a vehicle using the example of an airport bus.Such modeling will allow automating the process of optimizing the layout of the salon, provide comfortable conditions for passengers and improve the fullness of the salon.When modeling the dynami

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